Zamora missed Sunday's 2-1 win over struggling Wigan because of an Achilles tendon injury, but Hodgson believes that Zamora - who scored in the 2-1 first leg victory over the German side - will be fit enough to lead the attack.
"Bobby suffers with his Achilles tendon, as do many players," said Hodgson. "The problem with those injuries is that if you get a kick on it, like he did the other day, it makes it worse. We were hoping he would recover in time to play against Wigan but didn't. The medical staff are optimistic he will recover in time for Thursday."
Zamora's replacement against Wigan, David Elm, only lasted until half-time after Hodgson admitted he blundered by selecting him.
Elm had not fully recovered from a virus and was taken to hospital as a precautionary measure.
"He was totally shattered at half-time," Hodgson added. "With hindsight I made the wrong decision playing him because he is in hospital at the moment on an ECG machine because the virus in his body is still there.
"I could see that he was struggling. I thought it was maybe because he had not played for a while and the pace of the game was beyond him.
"I suddenly realised at half-time I had made a big mistake and that I should never have thrust him into a game of this nature. The illness took more out of him than I thought."
Source: PA
Source: PA