The full back has been out of action since picking up a serious knee injury in the Cottagers' west London derby defeat against Chelsea in December.
The injury ruled Pantsil out of the African Nations Cup and the majority of Fulham's march through Europe which has seen them beat Juventus and Shakhtar Donetsk to make the semi finals, where they will meet Hamburg next week.
Pantsil had to undergo an operation to cure the problem with his posterior cruciate ligament in January before returning to training three weeks ago.
Since then the defender has played three reserve games and he is now hoping to play some part in Fulham's bid to win their first major European competition.
"To play a full 90 minutes against Aston Villa's reserves on Monday was fantastic and I'm looking to be involved with the first team again very soon," the 28-year-old told Fulham's official club website.
"The injury happened on the last day before leaving to join my colleagues in the African Cup of Nations so I missed out on the African Cup of Nations and also all the Europa League games and I nearly lost the World Cup.
"We all started the season together but my injury pushed me away from competing in the Europa League competition.
"The boys are doing so well and I'm really pleased with their performances but on the other hand I'm not happy that I'm not involved."
Source: Team Talk